Oxidative Phosphorylation in Neurospora Mitochondria
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Oxidative phosphorylation in cardiolipin-lacking yeast mitochondria.
The role of cardiolipin in mitochondrial energy transformation was studied by comparing oxidative phosphorylation in the Saccharomyces cerevisiae cardiolipin synthase null mutant crd1Delta, and in isogenic wild type. Oxygen consumption experiments and membrane potential kinetics during the phosphorylation cycle in isolated mitochondria indicated that the absence of cardiolipin causes only a mod...
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2.5. hloore, A. I,., I>ay, 1). A,, Dry, 1. H. and Wiskich, J. 7’. (1000) in [Highlights in IJbiquinone Research (I,enaz, G.9 Ilarnebei, O., Rabbi. A. and Hattino, M., eds.), pp. 170173. Taylor and Francis, London 2(1. tiroger, A. ;und tilingenberg, M. ( 1 973) Eur. J. Hiochem. 24, 358-368 27. Dry, I. R. Moore. A. I,.. Day, I). A. and Wiskich, J. T. ( I O X O ) Arch. Hiochem. Hiophys. 273, 148-1...
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tion. Particulate fractions are obtained by the usual centrifugation procedures. The capacity of the isolated mitochondrial fraction to undergo oxidative phosphorylation was investigated. Mitochondria were found to be active with the sub strates succinate, malate, and glutamate, and P/O ratios approaching the theoretical were obtained. The use of malonate in conjunction with glutamate oxidation...
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Intrauterine growth retardation (IUGR) has been linked to the development of type 2 diabetes in adulthood. We have developed an IUGR model in the rat whereby the animals develop diabetes between 3 and 6 mo of age that is associated with insulin resistance. Alterations in hepatic glucose metabolism are known to contribute to the hyperglycemia of diabetes; however, the mechanisms underlying this ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1972
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)44990-9